产品货号：
Z20101
中文名称：
MCL1抗体
英文名称：
Anti-MCL1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MCL1 Antibody |
| 指标别名 | EAT;Mcl 1;Mcl 1l;Mcl 1s Delta TM;MCL1;mcl1/EAT;MCL1L;MCL1S;TM |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | MCL1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human MCL1 recombinant protein (Position:M1-R350).Human MCL1 shares 82% and 78% amino acid (aa) sequences identity with mouse and rat MCL1,respectively. |
| 实际分子量 | 37KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MCL1,also known as myeloid cell leukemia 1,is a protein that in humans is encoded the MCL1 gene.It is mapped to 1q21.3.MCL1 is a potent multidomain antiapoptotic protein of the BCL2 family that heterodimerizes with other BCL2 family members to protect against apoptotic cell death.MCL1 as an attractive candidate for regulation of hematopoietic stem cell homeostasis that is highly expressed in hematopoietic stem cells and regulated by growth factor signals.MCL1 is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors.During mitotic arrest,MCL1 protein levels decline markedly,through a posttranslational mechanism,potentiating cell death.Phosphorylation of MCL1 directs its interaction with the tumor suppressor protein FBW7,which is the substrate-binding component of a ubiquitin ligase complex. |
| Uniprot ID | Q07820 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | myeloid cell leukemia 1 |
| 蛋白名全称 | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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